NY bride who faked cancer sentenced to time served

[ [ [['Connery is an experienced stuntman', 4]], ' http://yhoo.it/KpUoHO', '[Slideshow: Death-defying daredevils]', ' ', '630', ' ', ' ', ], [ [['know that we have confidence in', 3]], 'http://yhoo.it/LqYjAX ', '[Related: The Secret Service guide to Cartagena]', ' ', '630', ' ', ' ', ], [ [['We picked up this other dog and', 5]], 'http://yhoo.it/JUSxvi', '[Related: 8 common dog fears, how to calm them]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 5]], 'http://bit.ly/JnoJYN', '[Related: Did WH share raid details with filmmakers?]', ' ', '630', ' ', ' ', ], [ [['accused of running a fake hepatitis B', 3]], 'http://bit.ly/KoKiqJ', '[Factbox: AQAP, al-Qaeda in Yemen]', ' ', '630', ' ', ' ', ], [ [['have my contacts on or glasses', 3]], 'http://abcn.ws/KTE5AZ', '[Related: Should the murder charge be dropped?]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 5]], 'http://yhoo.it/JD7nlD', '[Related: Bristol Palin reality show debuts June 19]', ' ', '630', ' ', ' ', ], [ [['have made this nation great as Sarah Palin', 1]], 'http://bit.ly/JRPFRO', '[Related: McCain adviser who vetted Palin weighs in on VP race]', ' ', '630', ' ', ' ', ], [ [['A JetBlue flight from New York to Las Vegas', 3]], 'http://yhoo.it/GV9zpj', '[Related: View photos of the JetBlue plane in Amarillo]', ' ', '630', ' ', ' ', ], [ [['the 28-year-old neighborhood watchman who shot and killed', 15]], 'http://news.yahoo.com/photos/white-house-stays-out-of-teen-s-killing-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120411/martinzimmermen.jpg', '630', ' ', 'AP', ], [ [['Titanic', 7]], 'http://news.yahoo.com/titanic-anniversary/', ' ', 'http://l.yimg.com/a/p/us/news/editorial/b/4e/b4e5ad9f00b5dfeeec2226d53e173569.jpeg', '550', ' ', ' ', ], [ [['He was in shock and still strapped to his seat', 6]], 'http://news.yahoo.com/photos/navy-jet-crashes-in-virginia-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/cv/ip/ap/default/120406/jet_ap.jpg', '630', ' ', 'AP', ], [ [['xxxxxxxxxxxx', 11]], 'http://news.yahoo.com/photos/russian-grannies-win-bid-to-sing-at-eurovision-1331223625-slideshow/', 'Click image to see more photos', 'http://l.yimg.com/a/p/us/news/editorial/1/56/156d92f2760dcd3e75bcd649a8b85fcf.jpeg', '500', ' ', 'AP', ] ]

[ [ [['did not go as far his colleague', 8]], '29438204', '0' ], [ [[' the 28-year-old neighborhood watchman who shot and killed', 4]], '28924649', '0' ], [ [['because I know God protects me', 14], ['Brian Snow was at a nearby credit union', 5]], '28811216', '0' ], [ [['The state news agency RIA-Novosti quoted Rosaviatsiya', 6]], '28805461', '0' ], [ [['measure all but certain to fail in the face of bipartisan', 4]], '28771014', '0' ], [ [['matter what you do in this case', 5]], '28759848', '0' ], [ [['presume laws are constitutional', 7]], '28747556', '0' ], [ [['has destroyed 15 to 25 houses', 7]], '28744868', '0' ], [ [['short answer is yes', 7]], '28746030', '0' ], [ [['opportunity to tell the real story', 7]], '28731764', '0' ], [ [['entirely respectable way to put off the searing constitutional controversy', 7]], '28723797', '0' ], [ [['point of my campaign is that big ideas matter', 9]], '28712293', '0' ], [ [['As the standoff dragged into a second day', 7]], '28687424', '0' ], [ [['French police stepped up the search', 17]], '28667224', '0' ], [ [['Seeking to elevate his candidacy back to a general', 8]], '28660934', '0' ], [ [['The tragic story of Trayvon Martin', 4]], '28647343', '0' ], [ [['Karzai will get a chance soon to express', 8]], '28630306', '0' ], [ [['powerful storms stretching', 8]], '28493546', '0' ], [ [['basic norm that death is private', 6]], '28413590', '0' ], [ [['songwriter also saw a surge in sales for her debut album', 6]], '28413590', '1', 'Watch music videos from Whitney Houston ', 'on Yahoo! Music', 'http://music.yahoo.com' ], [ [['keyword', 99999999999999999999999]], 'videoID', '1', 'overwrite-pre-description', 'overwrite-link-string', 'overwrite-link-url' ] ]

tom watson kawasaki disease resurrection masters tickets one direction tulsa news scalloped potatoes

Sharp drop in UK retail sales boosts stimulus case

LONDON (AP) ? Retail sales fell sharply in Britain during the wettest April in a century, official data showed Wednesday, a piece of bad economic news which analysts say could help prod the Bank of England to approve more monetary stimulus.

The Office for National Statistics said the volume of sales in April dropped 2.3 percent from March and 1.1 percent from a year earlier. Comparisons with last year were skewed by warm weather in 2011 and the wedding of Prince William and Kate Middleton, which had combined to boost spending, the agency said.

Special factors aside, the April sales drop weighs down on hopes that Britain's economy will break out of recession in the second quarter, said Howard Archer, European economist for IHS Global Insight.

"It is evident that there are currently a lot of pressures on consumers as they face uncertain and worrying times," Archer said.

The weak figures ? combined with a sharp drop in inflation in April to 3 percent ? have fueled expectations that the Bank of England will have to approve more monetary stimulus this year. On Tuesday, the International Monetary Fund urged both the coalition government and the central bank to do more to boost economic activity.

Minutes from the last meeting of the Bank's Monetary Policy Committee showed that several members thought the factors for and against more stimulus were "finely balanced," though only one of the nine members voted to expand the 325 billion pounds ($510 billion) stimulus program of asset purchases, known as quantitative easing. All nine members voted to keep the key interest rate at the all-time low of 0.5 percent.

"It still looks like it won't take much to tip the committee into doing more QE," said Samuel Tombs, U.K. economist at Capital Economics. "Indeed, if we continue to see data as weak as April's retail sales figures, then a resumption to QE may only be a couple of months away."

David Miles was for the second consecutive month the only member of the rate-setting MPC to have voted for more economic stimulus this month, according to minutes of the meeting published Wednesday. However, several members ? the minutes didn't say how many ? thought the decision was finely balanced.

The IMF said Britain needs looser monetary policy, perhaps even through a cut in interest rates.

But MPC members "felt that the existing stock of past (asset) purchases, together with the low level of bank rate, would continue to impart a substantial monetary stimulus to the economy for some time to come," the minutes said.

They also expressed concern that an extra holiday in June to mark the Diamond Jubilee of Queen Elizabeth II was likely to reduce output in the second quarter, though they expected a boost from the Olympic Games in the July-September quarter.

porphyria cinnamon rolls krampus robert de niro winner of x factor cheesecake recipe leona lewis

Memorial Day Schedules 2012 - Cornerstone Health & Fitness

Posted on Monday, May 21, 2012 under News & Updates with No Comments

Memorial Day is Monday, May 28th. The Clubs will be open from 7:00am ? 1:00pm, the playroom will be open 8:30am ? 12:00pm. Have a wonderful & safe weekend!!

DOYLESTOWN

• 7:45am Zone with Nick Benner
• 8:00am Pilates Mat Express with Suzanne Brett (Yoga Studio)
• 8:30am Group Power with Joanne Atkinson
• 9:00am Spin with Mary Ermigiotti
• 9:00am Vinyasa with Suzanne Brett (75 min.)
• 9:00am Zone with Nick Benner
• 9:40am Group Kick with Heather Costigan

NEW HOPE & THE TREEHOUSE

• 8:00am IM=X Pilates Mat Express with Colby (Treehouse)
• 8:30am Spin with Robin
• 9:00am IM=X Reformer with Colby
• 9:00am Group Power with Gina
• 9:00am Yoga Sculpt with Susanne P. (Treehouse)
• 9:00am Peak Fit with Matt
• 10:15am Zumba with Marilyn
• 10:30am Hatha with Susanne P. (75 min., Treehouse)

WARRINGTON

• 8:00am Pilates Mat Express with Suzanne T. (Yoga Studio)
• 8:30am TNT with Kathleen
• 9:00am Reformer with Suzanne T.
• 9:00am FIT with Sabrina
• 9:30 am Spin with Kathleen
• 9:30am Zumba with Laura
• 9:30am Hydro Fusion with Barb W.
• 9:45am Yoga Gently with Anne F. (75 min.)

For more information, please visit the Service Desk.

tu pac hologram shuttle pippa middleton space shuttle discovery kevin youkilis spacex ann romney

Why Pakistan still hasn't reopened NATO supply lines

The government of Pakistan is facing domestic political pressure to keep NATO's supply routes to Afghanistan closed, while the US resists apologizing or paying a high per truck fee.

By Mahvish Ahmad,?Correspondent / May 20, 2012

After receiving a last-minute invite to today's NATO summit in Chicago, Pakistan still has not come to a deal with the US to reopen supply lines for the Afghan war.?

Skip to next paragraph

' + google_ads[0].line2 + '
' + google_ads[0].line3 + '

'; } else if (google_ads.length > 1) { ad_unit += ''; } } document.getElementById("ad_unit").innerHTML += ad_unit; google_adnum += google_ads.length; return; } var google_adnum = 0; google_ad_client = "pub-6743622525202572"; google_ad_output = 'js'; google_max_num_ads = '1'; google_feedback = "on"; google_ad_type = "text"; google_adtest = "off"; google_image_size = '230x105'; google_skip = '0'; // -->

"We are close to a solution, but still have some way to go," says Fawad Chaudhury, the spokesperson for Pakistan's Prime Minister Yousaf Raza Gilani.

The closed route has been a bone of contention between the US and Pakistan ever since NATO forces attacked two military checkpoints in Salala, along the Pakistan-Afghanistan border, killing 24 Pakistani soldiers and injuring an additional 13. In response to the attack, the Pakistanis shut down the supply routes running through their territory, forcing NATO to use air transport and ground routes through Central Asia instead.

In the run-up to today's Chicago summit, the Pakistani government has faced countervailing pressures, with NATO and Washington pushing Pakistan to reopen the supply lines, and domestic opposition parties pushing to keep them closed.?A gradual democratization of Pakistan's foreign policy ??once the preserve of the military ??has added many voices across the political?spectrum into the debate over the NATO supply routes.

Parliament wants its say

On April 12 the Pakistani parliament passed a 14-point resolution in response to the Salala checkpoint attacks. The resolution condemns the attacks, and includes demands for an unconditional apology from the US, an immediate cessation of drone attacks, and a stop to all transport of arms and ammunition through Pakistan.?

The foreign policy review process was an attempt by the parliament to regain control over the country's foreign policy, which has historically been set by the country's military. It was passed after several months debate, and under a broad coalition of parties across the political spectrum.

?We need to make sure that we follow the recommendations of the parliament in our negotiations with the US. I am hopeful that we can come to a mutually satisfying agreement,? says Mr. Chaudhury.

US not budging on apology

The US, however, does not seem to be budging on the question of an apology. ?We have expressed our deepest condolences on this event, and are working hard to ensure that this event does not happen again,? says the spokesperson for the US State Department in Islamabad, Mark Stroh.?

The unlikelihood that some of the core demands of the resolution will be met, has given opposition parties ? especially those critical of US foreign policy ? ammunition against the current negotiations.

?We believe that Pakistan has suffered enormously because of this so-called war against terror. That is why we are calling for an end to the partnership. We do not want to see any NATO supply routes reopened, because we believe that is equal to aiding the US war effort in Afghanistan.?We will only reopen them, if it facilitates the withdrawal of foreign troops from our region,? says Shafqat Mehmood, the spokesperson for the Pakistan Tehreek-e-Insaaf (PTI). The party is led by the former cricket star-turned-politician, Imran Khan, who has earned political points on his criticism of US foreign policy.

Raza Rumi, director of the Islamabad-based Jinnah Institute, says?public sentiment is a reflection of an irrational and impractical approach to the country's foreign policy and national interest.

truffles alabama vs lsu alabama vs lsu bcs championship game beyonce baby detroit auto show tebow broncos

Role of fusion gene in prostate cancer: Mutation found in half of all prostate cancers may lead to disease development

ScienceDaily (May 22, 2012) ? Up to half of all prostate cancer cells have a chromosomal rearrangement that results in a new "fusion" gene and formation of its unique protein -- but no one has known how that alteration promotes cancer growth. Now, Weill Cornell Medical College researchers have found that in these cancer cells, the 3-D architecture of DNA, wrapped up in a little ball known as a chromatin, is warped in such a way that a switch has been thrown on thousands of genes, turning them on or off to promote abnormal, unchecked growth. Researchers also found that new chromosomal translocations form, further destabilizing the genome.

These findings, published in the Proceedings of the National Academy of Sciences (PNAS), are the first to show how this chromosomal mutation likely contributes to early development of prostate cancer -- and suggests a model for how other chromosomal translocations, common to many tumor types, are linked to cancer formation and growth.

"This is likely a phenomenon that occurs in many types of cancers when oncogenic fusion genes are over-expressed," says the study's senior author, Dr. Mark A. Rubin, The Homer T. Hirst Professor of Oncology in Pathology and vice chair for experimental pathology at Weill Cornell Medical College.

Dr. Rubin adds that if such an oncogenic protein has the power to throw the switch on thousands of genes, a novel treatment may be able to turn that switch off. "If we understand how this works, then we may be able to borrow that trick to target many genes simultaneously. This discovery would hold a lot of promise for cancer therapy," he says.

The study also adds to the growing understanding of how remodeling of the chromatin regulates genes linked to cancer, says the study's lead author, Dr. David S. Rickman, assistant professor of pathology and laboratory medicine at Weill Cornell Medical College. The genome's DNA, along with specialized proteins, has to be packed into the chromatin bundle so that it can fit inside a cell's nucleus, and when genes need to be expressed, the chromatin opens up a bit, allowing transcription. Emerging evidence suggests that, within this package, the genome organizes itself according to a non-randomly-assembled, 3-D architecture of hubs and domains that affect when and where individual genes are turned on.

This study shows the oncogenic ERG protein, produced by the ETS prostate cancer fusion gene, binds to specific sites in the genome, which then forces the 3-D genome architecture to vastly change, creating different hubs and domains, Dr. Rickman says. This results in additional chromosomal translocations, as well as a coordinated expression of genes known to be relevant to aggressive prostate cancer, he says.

The research shows just how complex genetic regulation really is and how distortions in this process can lead to cancer, says Dr. Rubin, who is also a professor of pathology and laboratory medicine and professor of pathology in urology at Weill Cornell Medical College.

"We used to think everything related to gene expression was linear, that one promoter affected the gene located right next to it," he says. "Now we are beginning to understand that what happens in the 3-D space of tightly bundled DNA is also important -- how DNA opens up and undergoes changes that efficiently turn on whole sets of genes that aren't located anywhere near each other."

It Takes a Village -- of Scientists

Reaching these findings required a collaborative team of scientists, says Dr. Rubin, who co-discovered the ETS fusion gene. For this project, he sought the expertise of Dr. Rickman and Dr. Olivier Elemento, an assistant professor in the Department of Physiology and Biophysics and assistant professor of computational genomics in the Institute for Computational Biomedicine at Weill Cornell Medical College, and a co-senior author of the paper. Dr. Elemento and his lab provided the expertise in computational biology and mathematical analysis needed to interpret the complex data produced by the experiments run by Dr. Rickman, his lab and members of the Rubin laboratory.

Joining them were nine other scientists from Weill Cornell Medical College, and two from Mount Sinai School of Medicine.

Dr. Elemento, Dr. Rickman and their laboratory colleagues used numerous techniques to understand the effect of the ERG oncoprotein. They first used an experimental technique called Hi-C to query chromatin interactions throughout the genome. "Chromatin interactions are inherently complex and it is easy to grasp why this is so," says Dr. Elemento. "There are about 25,000 known genes in the human genome therefore there are possibly 25,000 x 25,000 interactions between genes -- which is 625 million -- and that is only scratching the surface."

To treat the high volume of data the researchers needed to develop new statistical methods to detect chromatin interactions and the changes that occur when ERG is over-expressed.

Then, to understand why these chromatin interaction changes occurred in the first place -- what it is that ERG does to generate new interactions or abolish existing ones -- they performed additional experiments, which produced even more data. They used a technique called ChIP-seq to map where on the genome ERG likes to bind, and then used the RNA-seq tool to determine which genes are expressed or shut down when ERG is present.

More analyses were needed to identify genes and regions on the genome whose interaction patterns changed most when ERG was over-expressed. Finally, they reached what Dr. Elemento called a shocking revelation: "ERG binds very often near the genes whose interaction patterns change the most, thus indicating that ERG directly mediates the interaction by binding to these regions."

The researchers then discovered that genes whose expression was collectively increased or shut down, and which were involved in chromatin interactions, were those that are involved in cell invasion, a key feature of aggressive prostate cancer. "We thus think that ERG may contribute to prostate cancer phenotype by rearranging chromatin interactions to promote the expression of these key malignancy genes," Dr. Elemento says.

ERG also seems to push the formation of new chromosomal translocations, he says. "This is exciting because it points to a completely novel, non-transcriptional role for ERG in cancer," Dr. Elemento says. "We think that it is possible that many genes like ERG -- which bind to the DNA -- could promote the formation of novel genetic alterations by rearranging chromatin interactions."

Dr. Rickman agrees, "These findings extend beyond the context of the prostate as many driving genetic lesions in other cancer types involve abnormal expression of transcription factors due to genomic alterations."

The researchers are now conducting studies to unravel the mechanism that accounts for these architectural changes. "Achieving this will provide a new understanding of cancer and novel ways to treat and prevent its progression," Dr. Rickman says.

The work was supported by funding from a U.S. Department of Defense New Investigator Award, a National Science Foundation CAREER Grant, a National Institutes of Health National Cancer Institute Grant and by the Starr Cancer Consortium.

Other co-authors include Dr. T. David Soong, Benjamin Moss, Dr. Juan Miguel Mosquera, Jan Dlabal, Dr. St?phane Terry, Theresa Y. MacDonald, Dr. Karen Bunting, Dr. Francesca Demichelis and Dr. Ari M. Melnick from Weill Cornell Medical College; and Joseph Tripodi and Dr. Vesna Najfeld from Mount Sinai School of Medicine.

Share this story on Facebook, Twitter, and Google:

Other social bookmarking and sharing tools:

---

Story Source:

The above story is reprinted from materials provided by NewYork-Presbyterian Hospital/Weill Cornell Medical Center/Weill Cornell Medical College, via Newswise.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.

---

Journal Reference:

1. D. S. Rickman, T. D. Soong, B. Moss, J. M. Mosquera, J. Dlabal, S. Terry, T. Y. MacDonald, J. Tripodi, K. Bunting, V. Najfeld, F. Demichelis, A. M. Melnick, O. Elemento, M. A. Rubin. Oncogene-mediated alterations in chromatin conformation. Proceedings of the National Academy of Sciences, 2012; DOI: 10.1073/pnas.1112570109

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

cagayan de oro cagayan de oro bowl schedule 2011 bowl schedule barry bonds hazing colton harris moore

Video: Round the Table

A Second Take on Meeting the Press: From an up-close look at Rachel Maddow's sneakers to an in-depth look at Jon Krakauer's latest book ? it's all fair game in our "Meet the Press: Take Two" web extra. Log on Sundays to see David Gregory's post-show conversations with leading newsmakers, authors and roundtable guests. Videos are available on-demand by 12 p.m. ET on Sundays.

howard stern free shipping day free shipping day golden globe nominations 2012 war in iraq war in iraq government shutdown

Video: NATO Comes to Chicago

CNBC's Phil LeBeau reports on the NATO Summit underway in Chicago, where protesters are taking every opportunity to make themselves heard.

Related Links:

Business & financial news headlines from msnbc.com

Top of page

ncaa football brian van gorder blazing saddles lsu alabama lsu game lsu game beezow doo doo zopittybop bop bop